methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

Base Information

Chemical Name:methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate
CAS No.:83894-72-8
Molecular Formula:C₂₂H₂₅ClN₂O₃
Molecular Weight:400.905
Hs Code.:

Synonyms:methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

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Technology Process of methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

There total 15 articles about methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.1%

: 83894-72-8
methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

Guidance literature:

Reference yield:

: 99-75-2
4-methyl-benzoic acid methyl ester

: 83894-72-8
methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / N-bromosuccinimide, dibenzoyl-peroxide / CCl₄ / 2.5 h / Heating

2: 54 percent / dimethylsulfoxide / 2 h / 40 °C

3: HCl / 8 h / Heating

4: aq. NaHCO₃ / diethyl ether

5: 74 percent / NaOH / methanol / 4 h / 50 °C

6: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 1 h, 2.) THF, RT, overnight

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; dibenzoyl peroxide; In methanol; tetrachloromethane; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/jm9810349

Reference yield:

: 34595-33-0
5-amino-2-(piperidin-1-yl)benzonitrile

: 83894-72-8
methyl 4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) aq. NaNO₂, HCl, 2.) Cu, HCl / 1.) from 0 deg C to 4 deg C, 2.) 20 deg C, 4 h

2: aq. KOH / 1.5 h / 160 °C

3: 18 percent aq. HCl / 7 h / Heating

4: 60 percent / HCl / 8 h / Heating

5: 91 percent / LiAlH₄ / 3 h / -30 °C

6: 93 percent / SOCl₂ / CHCl₃ / 2 h / Ambient temperature

7: 74 percent / dimethylformamide / 2 h / 90 °C

8: 80 percent / 80 percent aq. N₂H₄ / ethanol / 10 h / Heating

9: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 1 h, 2.) THF, RT, overnight

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; copper; hydrazine hydrate; 1,1'-carbonyldiimidazole; sodium nitrite; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm9810349