3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide

Base Information

Chemical Name:3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide
CAS No.:916992-53-5
Molecular Formula:C₃₁H₃₆BrN₅O₄
Molecular Weight:622.562
Hs Code.:

Synonyms:3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide

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Chemical Property of 3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide

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Technology Process of 3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide

There total 4 articles about 3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869959-33-1
[1-(3-bromo-benzylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 916992-53-5
3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

1.2: Et₃N; HOBt; EDC / CH₂Cl₂; dimethylformamide / 0 - 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

2.2: Et₃N; HOBt; EDC / CH₂Cl₂; dimethylformamide / 0 - 20 °C

3.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

3.2: Et₃N; HOBt; EDC / CH₂Cl₂; dimethylformamide / 0 - 20 °C

4.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo061366i

Reference yield:

: {(S)-1-[(S)-1-(3-Bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid tert-butyl ester

: 916992-53-5
3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

1.2: Et₃N; HOBt; EDC / CH₂Cl₂; dimethylformamide / 0 - 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

2.2: Et₃N; HOBt; EDC / CH₂Cl₂; dimethylformamide / 0 - 20 °C

3.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo061366i

Reference yield:

: 916992-52-4
(1-{1-[1-(3-bromobenzylcarbamoyl)ethylcarbamoyl]-2-methylpropylcarbamoyl}-2-phenylethyl)carbamic acid tert-butyl ester

: 916992-53-5
3-Amino-N-((S)-1-{(S)-1-[(S)-1-(3-bromo-benzylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

1.2: Et₃N; HOBt; EDC / CH₂Cl₂; dimethylformamide / 0 - 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo061366i