C₃₅H₅₂N₄O₆

Base Information

• Chemical Name: C₃₅H₅₂N₄O₆
• CAS No.: 1447811-70-2
• Molecular Formula: C₃₅H₅₂N₄O₆
• Molecular Weight: 624.821

Synonyms:C₃₅H₅₂N₄O₆

Chemical Property of C₃₅H₅₂N₄O₆

Chemical Property:

Purity/Quality:

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Technology Process of C₃₅H₅₂N₄O₆

There total 1 articles about C₃₅H₅₂N₄O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-1,3-cyclohexanedione (562-13-0) → C35H52N4O6 (1447811-70-2) + (S)-(2R,3aR,6S,8R,9aR,10aS)-7'-((S)-3,3-dimethyloxirane-2-carbonyl)-10a-hydroxy-1,1,6-trimethyl-3a-(methylamino)-2'-oxo-3,3a,4,6,7,8,9,9a,10,10a-decahydro-1H-spiro[cyclopenta[b]quinolizine-2,3'-indolin]-8-yl-2-(dimethylamino)-3-methylbutanoate (774233-49-7)

Guidance literature:

Multi-step reaction with 20 steps

1.1: camphor-10-sulfonic acid; orthoformic acid triethyl ester / dichloromethane / 72 h / 0 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 16 h / Inert atmosphere; Reflux

2.2: 0 °C

3.1: sodium hydride / mineral oil; diethyl ether / 1.5 h / 0 °C / Inert atmosphere

3.2: 6.5 h / 0 °C / Inert atmosphere

4.1: copper(l) cyanide / diethyl ether / 0.17 h / -50 °C / Inert atmosphere

4.2: 16 h / -35 - 20 °C / Inert atmosphere

5.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

5.3: 21 h / -78 - 20 °C / Inert atmosphere

6.1: caesium carbonate / methanol; tetrahydrofuran / 16 h / 65 °C / Inert atmosphere

6.2: 0.33 h / 0 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / 1,4-dioxane / 0.47 h / 100 °C / Inert atmosphere

8.1: magnesium / tetrahydrofuran; ethylene dibromide / 2.5 h / Inert atmosphere; Reflux

8.2: 16.75 h / -78 - 20 °C / Inert atmosphere

9.1: L-Selectride / tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

9.2: 0.33 h / Inert atmosphere

10.1: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere

11.1: dihydrogen peroxide; peracetic acid; sodium carbonate / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

11.2: 0.33 h / 0 °C / Inert atmosphere

12.1: water / 48 h / 100 °C / Inert atmosphere; Sealed tube

12.2: 20 °C / Inert atmosphere; Sealed tube

13.1: sulfuric acid / 44 h / Inert atmosphere; Reflux

14.1: triethylaluminum / tetrahydrofuran; toluene / 0.33 h / -78 °C / Inert atmosphere

14.2: 1.33 h / 0 - 20 °C / Inert atmosphere

14.3: 0.33 h / Inert atmosphere

15.1: pyridinium p-toluenesulfonate / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

15.2: 18 h / 20 °C / Inert atmosphere

16.1: acetic acid / dichloromethane / 72 h / 20 °C / Inert atmosphere

17.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 72 h / 80 °C / Inert atmosphere

18.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

19.1: 2-bromopyridine-N-oxide; C₁₈H₁₅AuP⁽¹⁺⁾*C₂F₆NO₄S₂^(1-)*C₇H₈ / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

20.1: diethylzinc; (1S,2S)-N-Methylpseudoephedrine; oxygen / toluene / 16 h / 0 - 20 °C / Inert atmosphere

With 2-bromopyridine-N-oxide; peracetic acid; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; sulfuric acid; camphor-10-sulfonic acid; C₁₈H₁₅AuP⁽¹⁺⁾*C₂F₆NO₄S₂^(1-)*C₇H₈; (1S,2S)-N-Methylpseudoephedrine; tetrabutyl ammonium fluoride; dihydrogen peroxide; diethylzinc; oxygen; triethylaluminum; copper(l) cyanide; pyridinium p-toluenesulfonate; L-Selectride; sodium hydride; sodium carbonate; caesium carbonate; magnesium; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; orthoformic acid triethyl ester; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; water; ethylene dibromide; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1021/ja405547f

upstream raw materials:

2,2-dimethyl-1,3-cyclohexanedione

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