562-13-0

Usage

Uses

Used in Pharmaceutical Production:
2,2-Dimethylcyclohexane-1,3-dione is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the creation of diverse drug molecules, contributing to the development of new medications for treating various diseases and conditions.
Used in Agrochemical Production:
In the agrochemical industry, 2,2-Dimethylcyclohexane-1,3-dione serves as a crucial building block for the synthesis of various agrochemicals. Its application in this field helps in the development of effective pesticides, herbicides, and other agricultural chemicals that enhance crop protection and yield.
Used in Fine Chemicals Production:
2,2-Dimethylcyclohexane-1,3-dione is utilized as a versatile reagent in the production of fine chemicals. Its ability to participate in various chemical reactions makes it a valuable component in the synthesis of specialty chemicals used in industries such as fragrances, dyes, and coatings.
Used as a Precursor in Synthesis:
2,2-Dimethylcyclohexane-1,3-dione acts as a precursor in the synthesis of a wide range of compounds. Its chemical properties enable it to be transformed into various derivatives, which can be further used in different applications across multiple industries.
Used as a Chelating Agent in Coordination Chemistry:
In coordination chemistry, 2,2-Dimethylcyclohexane-1,3-dione functions as a chelating agent. Its ability to form stable complexes with metal ions makes it a useful component in the development of coordination compounds with specific properties and applications in areas such as catalysis, materials science, and supramolecular chemistry.

InChI:InChI=1/C8H12O2/c1-8(2)6(9)4-3-5-7(8)10/h3-5H2,1-2H3

Upstream product

• 1193-55-1 2-methylcyclohexane-1,3-dione 
• 74-88-4 methyl iodide 
• 61447-86-7 (S)-3-hydroxy-2,2-dimethylcyclohexanone 
• 676-88-0 dimethyl(methylthio)sulfonium tetrafluoroborate 
• 29829-22-9 S-methyldibenzothiophenium tetrafluoroborate 
• 767-55-5 2,2,5,5-tetramethyl-1,3-dioxane 
• 6838-66-0 1,2-bis((trimethylsilyl)oxy)cyclopent-1-ene 
• 50786-07-7 2,2-dimethyl-1-oxa-spiro[2.4]heptan-4-one 
• 50650-22-1 GENERIC INORGANIC CATION; 3-oxo-cyclohex-1-enolate 
• 17530-69-7 3-chloro-5,5-dimethylcyclohex-2-en-1-one 
• 7732-18-5 water 
• 124015-87-8 2-methyl-1,3-cyclohexanedione-dimethylhydrazone 
• 1353094-16-2 3,3-dimethylcyclohex-5-ene-1,2,4-trione 
• 542-92-7 cyclopenta-1,3-diene 

Downstream Products

• 104093-17-6 1,2,2,3-tetramethyl-cyclohexane-1,3-diol 
• 7499-43-6 5,5,5',5'-tetramethyl-2,2'-heptylidene-bis-cyclohexane-1,3-dione 
• 19419-23-9 2,2'-phenylmethylene-bis(5,5-dimethylcyclohexane-1,3-dione) 
• 40564-61-2 5-keto-6-methylheptanoic acid 
• 2181-22-8 bis(5,5-dimethylcyclohexane-1,3-dione-2-yl)methane 
• 94759-76-9 1,1-Dimethyl-2,6-diphenyl-cyclohexandiol-(2,6) 
• 114693-83-3 rac-(R,R)-2,2-dimethylcyclohexane-1,3-diol 
• 24071-98-5 ethyl 5-oxo-5-isopropylpentanoate 
• 6328-22-9 3-isopropyl-2-cyclohexen-1-one 
• 75072-38-7 3,3,7,7-tetramethyl-1,5-dioxaspiro[5,5]undecan-8-one 
• 90925-59-0 (+/-)-3-Ethinyl-2,2-dimethyl-3-hydroxy-cyclohexan-1-on 
• 174578-97-3 3-Hydroxy-2,2-dimethyl-3-phenylcyclohexanone 
• 14782-52-6 ethylene glycole monoacetal of 2,2-dimethylcyclohexane-1,3-dione 
• 337466-23-6 4,6-dibromo-2,2-dimethyl-cyclohexane-1,3-dione 

Relevant academic research and scientific papers

Acylative desymmetrization of cyclic meso-1,3-diols by chiral DMAP derivatives

An efficient enantioselective acylative desymmetrization of cyclic meso-1,3-diols was developed by using a chiral DMAP derivative 1e having a 1,1¤-binaphthyl unit. The reactions required only 0.5mol% of the catalyst and showed good to excellent enantioselectivity. With this transformation, 5a, a key building block for the synthesis of natural products, was easily obtained in almost enantiomerically pure form after a single recrystallization. Control experiments revealed that tert-alcohol units on the catalyst were responsible for both the catalytic activity and enantioselectivity.

NRF 2 ACTIVATOR

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, which are activators of nuclear factor erythroid 2 (NF-E2) -related factor 2 (Nrf2) and are useful to treat diseases caused by oxidative stress, such as neurodegenerative diseases or inflammation. Also provided are methods for their use and production.

Four and ring kinase inhibitors

The invention belongs to the technical field of medicines and relates to a tetra-cyclo-kinase inhibitor shown in the general formula (I) and its pharmaceutically acceptable salt, stereisomer, ester or solvate. In the general formula (I), R1, R2, R3, R4, M, W, X, Y and Z are defined in the specification. The invention also relates to a preparation method of the compounds, a drug containing the compounds, and a use of the compounds and its pharmaceutically acceptable salt, stereisomer, ester or solvate in preparation of a drug for treating and/or preventing ALK-mediated cancer-related diseases.

Four and ring kinase inhibitors

The present invention relates to the field of medical technologies, in particular to a tetrazocyclokinase inhibitor as represented by general formula (I), stereoisomer thereof, or pharmaceutically acceptable salt, and ester or solvate thereof, wherein A1, A2, A3, A4, R1, R2, R3, R4, R5, R6, R7, M, X, Y, Q, and n are as defined in the specification. The present invention also relates to a method for preparing the compounds, and uses of a pharmaceutical formulation and pharmaceutical composition containing the compounds, and the compounds or stereoisomers thereof, or pharmaceutically acceptable salt, ester or solvate thereof in the preparation of drugs for treating and/or preventing ALK-mediated cancer-related diseases.

Synthesis of paclitaxel. 1. synthesis of the abc ring of paclitaxel by SmI2-mediated cyclization

A convergent synthesis of the ABC ring of antitumor natural product paclitaxel (Taxol) is described. SmI2-mediated reductive cyclization of an allylic benzoate possessing an aldehyde function, synthesized from tri-O-acetyl-d-glucal and 1,3-cyclohexanedione, smoothly afforded the highly strained 6-8-6 tricarbocyclic structure in 66% yield.

SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

The effect of Lewis acids on the cycloaddition of 3,3,6-Trimethylcyclohex- 5-ene-1,2,4-trione: Hydrogen transfer versus cycloaddition with cyclopentadiene

Exposure of 3,3,6-trimethylcyclohex-5-ene-1,2,4-trione to catalytic amounts of Lewis acids revealed two disparate reactions in the presence of cyclopentadiene. The expected cycloaddition was found to be reversible for the title compound, and transfer hydrogenation was the preferred pathway over long periods of time. Other tested substrates were able to undergo facile cycloaddition with considerable yields and without the parallel reduction. The work presented here defines the effect of Lewis acid catalysts on the reaction between cyclopentadiene and 3,3,6-trimethylcyclohex-5-ene-1,2,4-trione. Cycloaddition and hydrogenation reactions both occur in parallel. For cycloaddition, the dr was similar for all Lewis acids tested. Hydrogenation was catalyzed efficiently by AlCl3 and found to be the main mode of reaction for this particular system. Copyright

An unexpected directing effect in the asymmetric transfer hydrogenation of α,α-disubstituted ketones

α,α-Disubstituted ketones containing an aromatic ring or alkene are reduced in high enantiomeric excess using an asymmetric transfer hydrogenation catalyst. The sense of reduction indicates that the unsaturated region of the ketone adopts a position adjacent to the Ru-bound η6-arene ring in the reduction transition state.

Ionic liquid as catalyst and solvent: the remarkable effect of a basic ionic liquid, [bmIm]OH on Michael addition and alkylation of active methylene compounds

A basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmIm]OH, catalyzes the Michael addition of active methylene compounds to conjugated ketones, carboxylic esters and nitriles. It further catalyzes the addition of thiols to α,β-acetylenic ketones and alkylation of 1,3-dicarbonyl and -dicyano compounds. The Michael addition to α,β-unsaturated ketones proceeds in the usual way, giving the monoaddition products, whereas addition to α,β-unsaturated esters and nitriles leads exclusively to the bis-addition products. The α,β-acetylenic ketones undergo double conjugate addition with thiols producing β-keto 1,3-dithio-derivatives. In the alkylation reaction the acyclic 1,3-diketones are monoalkylated, whereas cyclic ketones undergo dialkylation under identical conditions. All these reactions were carried out without any organic solvent. The ionic liquid can also be recycled.

An NMR tool for cyclodextrin selection in enantiomeric resolution by high-performance liquid chromatography

Complexation-induced chemical shifts and diffusion coefficients (HR-DOSY) of enantiomers with native and derivatized cyclodextrins were used for calculations of the apparent binding constants of three cyclohexanone inclusion complexes. Correlations between these data and high-performance liquid chromatography were established, revealing that this approach can be applied as an alternative method to predict enantiomeric discrimination. Copyright