N¹-formyl-N⁷,N⁷-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine

Base Information

• Chemical Name: N¹-formyl-N⁷,N⁷-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine
• CAS No.: 124040-14-8
• Molecular Formula: C₂₂H₂₅N₃O₅S
• Molecular Weight: 443.524
• Mol file: 124040-14-8.mol

Synonyms:N¹-formyl-N⁷,N⁷-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine

Chemical Property of N¹-formyl-N⁷,N⁷-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-formyl-N⁷,N⁷-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine

There total 4 articles about N¹-formyl-N⁷,N⁷-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) + N1-formyl-N3-tosyl-1,3-propanediamine (107976-50-1) → N1-formyl-N7,N7-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine (124040-14-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1246/bcsj.62.198

Reference yield:

phthalimide (136918-14-4,85-41-6) → N1-formyl-N7,N7-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine (124040-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent

2: 93 percent / Cs₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1246/bcsj.62.198

Reference yield:

N-(N3-p-toluenesulfonyl)-3-aminopropylphthalimide (38353-77-4) → N1-formyl-N7,N7-phthaloyl-4-tosyl-4-azaheptane-1,7-diamine (124040-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄, / H₂O; dimethylformamide / 18 h / 75 °C

2: Cs₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With caesium carbonate; hydrazine; In water; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.62.1102

upstream raw materials:

2-(3-bromopropyl)isoindole-1,3-dione

N¹-formyl-N³-tosyl-1,3-propanediamine

3-(phthalimido)propyl-p-toluenesulfonate

phthalimide

Downstream raw materials:

N¹,N¹⁷,5,9,13-pentatosyl-5,9,13-triazaheptadecane-1,17-diamine

5,9,13-tritosyl-N¹,N¹:N¹⁷,N¹⁷-diphthaloyl-5,9,13-triazaheptadecane-1,17-diamine

5,9,13-tritosyl-N¹,N¹⁷-diformyl-5,9,13-triazaheptadecane-1,17-diamine

N⁷-formyl-N¹,4-ditosyl-4-azaheptane-1,7-diamine