N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

Base Information

Chemical Name:N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine
CAS No.:1265217-39-7
Molecular Formula:C₂₀H₂₃FN₂O
Molecular Weight:326.414
Hs Code.:

Synonyms:N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

Suppliers and Price of N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

There total 13 articles about N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1265218-97-0
N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

: 1265217-39-7
N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

Guidance literature:: N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide; With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

With Glauber's salt; In tetrahydrofuran;

Reference yield:

: 886499-88-3
2-bromo-4-chloro-6-fluorophenol

: 1265217-39-7
N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium carbonate / acetone / 1.33 h / 20 °C

2.1: nitric acid; sulfuric acid / 2 h / 20 °C

3.1: hydrogenchloride; tin(ll) chloride / ethanol / 4 h / 20 °C

4.1: 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

5.2: 20 °C

6.1: N-ethyl-N,N-diisopropylamine; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

7.1: potassium carbonate / acetone / Reflux

8.1: triethylamine; hydrogen / palladium on carbon / methanol / 20 °C

9.1: sodium hydroxide; water / methanol / 1 h / Reflux

9.2: pH 7

10.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

11.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 20 °C

With hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; nitric acid; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; sodium hydroxide; palladium on carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: methyl 4-(N-(2-bromo-6-chloro-3-ethoxy-4-fluorophenyl)acetamido)but-2-enoate

: 1265217-39-7
N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / acetone / Reflux

3.1: triethylamine; hydrogen / palladium on carbon / methanol / 20 °C

4.1: sodium hydroxide; water / methanol / 1 h / Reflux

4.2: pH 7

5.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

6.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; tetrabutylammomium bromide; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium on carbon; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;