N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Base Information

Chemical Name:N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide
CAS No.:1265218-97-0
Molecular Formula:C₂₀H₂₁FN₂O₂
Molecular Weight:340.397
Hs Code.:

Synonyms:N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

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Chemical Property of N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Chemical Property:

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Technology Process of N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

There total 12 articles about N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1265218-96-9
2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid

: 100-46-9
benzylamine

: 1265218-97-0
N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1265218-86-7
1-bromo-5-chloro-2-ethoxy-3-fluorobenzene

: 1265218-97-0
N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 2 h / 20 °C

2.1: hydrogenchloride; tin(ll) chloride / ethanol / 4 h / 20 °C

3.1: 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

4.2: 20 °C

5.1: N-ethyl-N,N-diisopropylamine; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

6.1: potassium carbonate / acetone / Reflux

7.1: triethylamine; hydrogen / palladium on carbon / methanol / 20 °C

8.1: sodium hydroxide; water / methanol / 1 h / Reflux

8.2: pH 7

9.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

With hydrogenchloride; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; nitric acid; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; sodium hydroxide; palladium on carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 348-62-9
4-chloro-2-fluorophenol

: 1265218-97-0
N-benzyl-2-(4-ethoxy-5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: bromine / acetic acid / 20 °C

2.1: sodium carbonate / acetone / 1.33 h / 20 °C

3.1: nitric acid; sulfuric acid / 2 h / 20 °C

4.1: hydrogenchloride; tin(ll) chloride / ethanol / 4 h / 20 °C

5.1: 1 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

6.2: 20 °C

7.1: N-ethyl-N,N-diisopropylamine; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

8.1: potassium carbonate / acetone / Reflux

9.1: triethylamine; hydrogen / palladium on carbon / methanol / 20 °C

10.1: sodium hydroxide; water / methanol / 1 h / Reflux

10.2: pH 7

11.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

With hydrogenchloride; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; bromine; nitric acid; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; sodium hydroxide; palladium on carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide; acetone; mineral oil;