10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

Base Information

Chemical Name:10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione
CAS No.:93214-16-5
Molecular Formula:C₂₇H₂₃Cl₂N₃O₃
Molecular Weight:508.404
Hs Code.:

Synonyms:10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

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Chemical Property of 10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

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Technology Process of 10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

There total 5 articles about 10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 3644-56-2
2-chloro-N-(2,6-dichlorophenyl)acetamide

: 93214-09-6
10,10-Dimethyl-6,7,9,10-tetrahydro-5H-14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

: 93214-16-5
10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 75 - 80 ℃; for 4h;
DOI:10.1002/jhet.5570210424

Reference yield:

: 56946-77-1
4,4-Dimethyl-1-(2'-nitrophenyl)-1,4-dihydro-3(2H)-isoquinolinone

: 93214-16-5
10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Hydrogen / Pd/C / acetic acid / 0.33 h / 15001.2 - 18751.5 Torr / Ambient temperature

2: 90 percent / Triethylamine / acetic acid / 6 h / 50 - 55 °C

3: 80 percent / Sodium hydride, sodium hydroxide / dimethylsulfoxide / 1.5 h / 32 - 35 °C

4: 35 percent / Sodium hydride / dimethylsulfoxide; dimethylformamide / 4 h / 75 - 80 °C

With sodium hydroxide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570210424

Reference yield:

: 5470-47-3
(±)-3-methyl-2-phenylbutyramide

: 93214-16-5
10,10-Dimethyl-6,7,9,10-tetrahydro-5-(2,6-dichloroacetanilido)-5H,14bH-isoquino<2,1-d><1,4>benzodiazepine-6,9-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Polyphosphoric acid / 5 h / 77 - 80 °C

2: 92 percent / Hydrogen / Pd/C / acetic acid / 0.33 h / 15001.2 - 18751.5 Torr / Ambient temperature

3: 90 percent / Triethylamine / acetic acid / 6 h / 50 - 55 °C

4: 80 percent / Sodium hydride, sodium hydroxide / dimethylsulfoxide / 1.5 h / 32 - 35 °C

5: 35 percent / Sodium hydride / dimethylsulfoxide; dimethylformamide / 4 h / 75 - 80 °C

With sodium hydroxide; PPA; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570210424