N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide

Base Information

Chemical Name:N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide
CAS No.:1452372-96-1
Molecular Formula:C₂₃H₄₁NO₃Si
Molecular Weight:407.669
Hs Code.:

Synonyms:N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide

Chemical Property:

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Technology Process of N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide

There total 2 articles about N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 13154-24-0
triisopropylsilyl chloride

: 1452372-75-6
4-hydroxy-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methylbutanamide

: 1452372-96-1
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.3762/bjoc.9.132

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 1452372-96-1
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; lithium chloride / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; lithium chloride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.3762/bjoc.9.132

Reference yield: 73.0%

: 1452372-96-1
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide

: 1452372-72-3
4(E)-1-(trityloxy)-4-iodobut-2-ene

: 1452372-99-4
(S,E)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-2-(2-(triisopropylsilyloxy)ethyl)-6-(trityloxy)hex-4-enamide

Guidance literature:: N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-4-((triisopropylsilyl)oxy)butanamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.33333h; Inert atmosphere;

4(E)-1-(trityloxy)-4-iodobut-2-ene; In tetrahydrofuran; hexane; at 0 ℃; for 2.5h; Inert atmosphere;
DOI:10.3762/bjoc.9.132