(R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide

Base Information

Chemical Name:(R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide
CAS No.:1595144-34-5
Molecular Formula:C₂₀H₂₀F₃N₅O
Molecular Weight:403.407
Hs Code.:

Synonyms:(R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide

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Chemical Property of (R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide

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Technology Process of (R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide

There total 3 articles about (R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1595144-12-9
(R)-N-(4-cyanophenylethyl)piperidine-3-carboxamide

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1595144-34-5
(R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 100 ℃; for 2h; Sealed tube;
DOI:10.1021/jm401731q

Reference yield:

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 1595144-34-5
(R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 25 °C

1.2: 25 °C

2.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 0 °C

2.2: pH 12

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 100 °C / Sealed tube

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm401731q

Reference yield:

: 167762-80-3
4‐(2‐aminoethyl)benzonitrile hydrochloride

: 1595144-34-5
(R)-N-(4-cyanophenylethyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 25 °C

1.2: 25 °C

2.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 0 °C

2.2: pH 12

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 100 °C / Sealed tube

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm401731q