benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

Base Information

Chemical Name:benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate
CAS No.:157919-58-9
Molecular Formula:C₂₂H₂₅NO₅
Molecular Weight:383.444
Hs Code.:

Synonyms:benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

Chemical Property:

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Technology Process of benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

There total 1 articles about benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4376-18-5
Monomethyl phthalate

: 16652-75-8
L-isoleucine benzyl ester tosylate

: 42406-41-7
benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

: 157919-58-9
benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

Guidance literature:: With thionyl chloride; triethylamine; N,N-dimethyl-formamide; Yield given; 1.) reflux, 1 h, 2.) benzene, 3.) THF, 0 deg C, 2 h;
DOI:10.1016/S0040-4020(01)85232-7

Reference yield: 88.0%

: 157919-58-9
benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

: 42406-41-7
benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; water; for 1.16667h;
DOI:10.1016/S0040-4020(01)85232-7

Reference yield:

: 157919-58-9
benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

: 29588-88-3
N-phthaloyl-L-isoleucine

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Bu₄NBr, 5percent NaOH / CH₂Cl₂; H₂O / 1.17 h

2: 99 percent / H₂ / 10percent Pd/C / ethanol

With sodium hydroxide; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)85232-7