Sulfonterol

Base Information

• Chemical Name: Sulfonterol
• CAS No.: 42461-79-0
• Molecular Formula: C₁₄H₂₃NO₄S
• Molecular Weight: 301.407
• Mol file: 42461-79-0.mol

Synonyms:Sulfonterol

Chemical Property of Sulfonterol

Chemical Property:

• Vapor Pressure: 1.65E-12mmHg at 25°C
• Boiling Point: 540.4°Cat760mmHg
• Flash Point: 280.6°C
• PSA: 95.01000
• Density: 1.216g/cm³
• LogP: 2.83000

Purity/Quality:

SULFONTEROL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Sulfonterol

There total 6 articles about Sulfonterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Benzyloxy-3-methylsulfonylmethyl-1-<2-(tert.-butylamino)-1-hydroxy-aethyl>-benzol → α-[(tert-butylamino)methyl]-4-hydroxy-3-(methylsulfonylmethyl)benzenemethanol (42461-79-0,56490-95-0,753392-49-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00241a006

Reference yield:

4-benzyloxy-3-methyl-sulfonylmethylacetophenone (49640-13-3) → α-[(tert-butylamino)methyl]-4-hydroxy-3-(methylsulfonylmethyl)benzenemethanol (42461-79-0,56490-95-0,753392-49-3)

Guidance literature:

Multi-step reaction with 5 steps

1: pyrrolidin-2-one hydrotribromide, pyrrolidin-2-one / tetrahydrofuran / Heating

2: dimethylsulfoxide

3: methanol

4: NaBH₄ / ethanol

5: H₂ / Pd-C / aq. ethanol

With 2-pyrrolidinon; sodium tetrahydroborate; pyrrolidone hydrotribromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00241a006

Reference yield:

4'-benzyloxy-2-bromo-3'-methylsulfonylmethylacetophenone (49638-94-0) → α-[(tert-butylamino)methyl]-4-hydroxy-3-(methylsulfonylmethyl)benzenemethanol (42461-79-0,56490-95-0,753392-49-3)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylsulfoxide

2: methanol

3: NaBH₄ / ethanol

4: H₂ / Pd-C / aq. ethanol

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00241a006

upstream raw materials:

4-benzyloxy-3-methyl-sulfonylmethylacetophenone

4'-benzyloxy-2-bromo-3'-methylsulfonylmethylacetophenone

1-(3-chloromethyl-4-hydroxyphenyl)ethanone

4-Benzyloxy-3-methylsulfonylmethyl-ω-(tert-butylimino)-acetophenon

Refernces