49638-94-0

Basic information

• Product Name: Ethanone, 2-bromo-1-[3-[(methylsulfonyl)methyl]-4-(phenylmethoxy)phenyl]-
• CAS NO: 49638-94-0
• Molecular Formula: C17H17BrO4S
• Molecular Weight: 397.29
• Mol File: 49638-94-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-bromo-1-[3-[(methylsulfonyl)methyl]-4-(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-1-[3-[(methylsulfonyl)methyl]-4-(phenylmethoxy)phenyl]-(49638-94-0)
• EPA Substance Registry System: Ethanone, 2-bromo-1-[3-[(methylsulfonyl)methyl]-4-(phenylmethoxy)phenyl]-(49638-94-0)

Safety Data

• Hazardous Substances Data: 49638-94-0(Hazardous Substances Data)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 52215-12-0 pyrrolidone hydrotribromide 
• 49640-13-3 4-benzyloxy-3-methyl-sulfonylmethylacetophenone 
• 99-93-4 4-Hydroxyacetophenone 
• 49640-12-2 4'-hydroxy-3'-methylsulfonylmethylacetophenone 
• 24085-05-0 1-(3-chloromethyl-4-hydroxyphenyl)ethanone 

Downstream Products

• 49640-16-6 4-benzyloxy-3-methylsulphonylmethylphenyl-glyoxal 
• 340159-36-6 4-Benzyloxy-3-methylsulfonylmethyl-ω-(tert-butylimino)-acetophenon 
• 42461-79-0 α-[(tert-butylamino)methyl]-4-hydroxy-3-(methylsulfonylmethyl)benzenemethanol 

Relevant articles and documents

α-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols having β-adrenergic stimulant activity

α-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols having β-adrenergic stimulant activity, particularly as selected bronchodilators, are prepared from 4-hydroxyphenones by conversion to a 3-alkylsulfonylmethylphenone, bromination of these phenones and treatment of the resulting α-bromo derivatives with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove the benzyl groups and reduce the ketone moiety.

N,N'-BIS[2-3-SUBSTITUTED-4-HYDROXYPHENYL)-2-HYDROXYETHYL)]-POLYMETHYLENEDIAMINES

N,N'-Bis 2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl!-polymethylenediamines having β-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an α-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.