bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite

Base Information

• Chemical Name: bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite
• CAS No.: 462102-49-4
• Molecular Formula: C₂₂H₃₀NO₃P
• Molecular Weight: 387.459
• Mol file: 462102-49-4.mol

Synonyms:bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite

Chemical Property of bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite

Chemical Property:

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Technology Process of bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite

There total 1 articles about bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

di(2,6-dimethoxyphenyl) chlorophosphite (22277-52-7) + (S)-2-hydroxymethyl-1-methylpyrrolidine (34381-71-0) → bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite (462102-49-4)

Guidance literature:

With triethylamine; In benzene; at 50 ℃; for 1h;

DOI:10.1002/1099-0682(200206)2002:6<1367::aid-ejic1367>3.0.co;2-f

Reference yield: 20.0%

di(rhodium)tetracarbonyl dichloride + bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite (462102-49-4) → [Rh(CO)(Cl)(bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite)] + trans-[Rh(CO)(Cl)(bis(2,6-dimethylphenyl) [(2S)-1-methylpyrrolidin-2-yl]methyl phosphite)2]

Guidance literature:

In chloroform; byproducts: CO; under Ar, 2 equiv. of phosphite-compd. in CHCl3 was dropwise added a stirred soln. of Rh-compd. in CHCl3; not isolated, detected by IR and NMR;

DOI:10.1002/1099-0682(200206)2002:6<1367::aid-ejic1367>3.0.co;2-f

upstream raw materials:

di(2,6-dimethoxyphenyl) chlorophosphite

(S)-2-hydroxymethyl-1-methylpyrrolidine