ethyl 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate
• CAS No.: 1609165-76-5
• Molecular Formula: C₁₈H₁₆F₂N₂O₃
• Molecular Weight: 348.318

Synonyms:ethyl 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Chemical Property of ethyl 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Chemical Property:

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Technology Process of ethyl 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate

There total 4 articles about ethyl 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,6-difluorobenzoate (13671-00-6) → ethyl 8-{[(2,6-difluorophenyl)(2H2)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate (1609165-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium deuteride / tetrahydrofuran / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With lithium aluminium deuteride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene;

Reference yield:

2-amino-3-benzyloxypyridine (24016-03-3) → ethyl 8-{[(2,6-difluorophenyl)(2H2)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate (1609165-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 48 h / 100 °C / Molecular sieve

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In ethanol; ethyl acetate; toluene;

Reference yield:

ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 8-{[(2,6-difluorophenyl)(2H2)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate (1609165-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 48 h / 100 °C / Molecular sieve

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In ethanol; ethyl acetate; toluene;

upstream raw materials:

methyl 2,6-difluorobenzoate

2-amino-3-benzyloxypyridine

ethyl 2-chloro-3-oxo-butyrate

2-carboethoxy-3-methyl-8-(phenylmethoxy)imidazo<1,2-a>pyridine

Downstream raw materials:

8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

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