(3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester

Base Information

Chemical Name:(3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester
CAS No.:1325688-50-3
Molecular Formula:C₁₂H₁₄N₄O₄
Molecular Weight:278.268
Hs Code.:

Synonyms:(3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester

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Chemical Property of (3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester

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Technology Process of (3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester

There total 3 articles about (3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1325688-50-3
(3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 16h;

Reference yield:

: C₂₁H₃₄N₄O₄Si

: 1325688-50-3
(3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2014.12.065

Reference yield:

: 177966-65-3
methyl (3S)-3-amino-3-(4-hydroxyphenyl)propanoate

: 1325688-50-3
(3S)-(2-azido-acetylamino)-3-(4-hydroxy-phenyl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane

2.2: -10 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 8 h / 80 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 20 °C

With sodium azide; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.12.065