3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

Base Information

Chemical Name:3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide
CAS No.:774213-89-7
Molecular Formula:C₂₅H₂₉N₃O₂
Molecular Weight:403.524
Hs Code.:

Synonyms:3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

Suppliers and Price of 3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

There total 7 articles about 3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 735282-93-6
3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxylic acid

: 774213-89-7
3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

Guidance literature:: With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate; In DMF (N,N-dimethyl-formamide); for 72h;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 774213-89-7
3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: aq. Na₂CO₃ / Pd(PPh₃)2Cl₂ / dioxane / Heating

2: 95 percent / NaH / dimethylformamide / 60 °C

3: 100 percent / CF₃CO₂H / CH₂Cl₂ / 2 h

4: TBTU; i-Pr₂NEt / CH₂Cl₂ / 16 h

5: NaOH / dioxane; H₂O / 60 °C

6: (Boc)2O; H₄NHCO₃; pyridine / dimethylformamide / 24 h

With pyridine; sodium hydroxide; di-tert-butyl dicarbonate; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.06.093

Reference yield:

: 98-80-6
phenylboronic acid

: 774213-89-7
3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: aq. Na₂CO₃ / Pd(PPh₃)2Cl₂ / dioxane / Heating

2: 95 percent / NaH / dimethylformamide / 60 °C

3: 100 percent / CF₃CO₂H / CH₂Cl₂ / 2 h

4: TBTU; i-Pr₂NEt / CH₂Cl₂ / 16 h

5: NaOH / dioxane; H₂O / 60 °C

6: (Boc)2O; H₄NHCO₃; pyridine / dimethylformamide / 24 h

With pyridine; sodium hydroxide; di-tert-butyl dicarbonate; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.06.093