3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester
• CAS No.: 160427-15-6
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.24

Synonyms:3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester

Chemical Property of 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester

There total 2 articles about 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl acrylate (140-88-5,9003-32-1) + 4-hydroxybenzaldehyde oxime (699-06-9,60221-52-5,60221-53-6) → 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester (160427-15-6)

Guidance literature:

With iodosylbenzene; cetyltrimethylammonim bromide; In water; at 20 ℃; for 3h;

DOI:10.1021/jo801337k

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + ethyl acrylate (140-88-5,9003-32-1) → 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester (160427-15-6)

Guidance literature:

Multistep reaction.;

DOI:10.1002/1099-0690(200204)2002:7<1175::aid-ejoc1175>3.3.co;2-q

Reference yield: 88.0%

3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester (160427-15-6) → 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester (160427-19-0)

Guidance literature:

With hydrogen; W-2 Raney nickel; In methanol; acetic acid; for 5h; Ambient temperature;

DOI:10.1055/s-1994-25663

upstream raw materials:

ethyl acrylate

4-hydroxybenzaldehyde oxime

4-hydroxy-benzaldehyde

Downstream raw materials:

2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester

6-(4-hydroxyphenyl)-3(2H)-pyridazinone

4-Hydroxy-6-(4-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

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