2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester

Base Information

• Chemical Name: 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester
• CAS No.: 160427-19-0
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol file: 160427-19-0.mol

Synonyms:2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester

Chemical Property of 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester

There total 3 articles about 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester (160427-15-6) → 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester (160427-19-0)

Guidance literature:

With hydrogen; W-2 Raney nickel; In methanol; acetic acid; for 5h; Ambient temperature;

DOI:10.1055/s-1994-25663

Reference yield:

ethyl acrylate (140-88-5,9003-32-1) → 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester (160427-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-chlorosuccinimide, pyridine; 2.) Et₃N / 1.) chloroform, 60 deg C, 30 min; 2.) 40-50 deg C, 20 min

2: 88 percent / hydrogen / W-2 Raney nickel / methanol; aq. acetic acid / 5 h / Ambient temperature

With pyridine; N-chloro-succinimide; hydrogen; triethylamine; W-2 Raney nickel; In methanol; acetic acid;

DOI:10.1055/s-1994-25663

Reference yield:

4-hydroxybenzaldehyde oxime (699-06-9,60221-52-5,60221-53-6) → 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester (160427-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-chlorosuccinimide, pyridine; 2.) Et₃N / 1.) chloroform, 60 deg C, 30 min; 2.) 40-50 deg C, 20 min

2: 88 percent / hydrogen / W-2 Raney nickel / methanol; aq. acetic acid / 5 h / Ambient temperature

With pyridine; N-chloro-succinimide; hydrogen; triethylamine; W-2 Raney nickel; In methanol; acetic acid;

DOI:10.1055/s-1994-25663

upstream raw materials:

3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester

ethyl acrylate

4-hydroxybenzaldehyde oxime

Downstream raw materials:

6-(4-hydroxyphenyl)-3(2H)-pyridazinone

4-Hydroxy-6-(4-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one