1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:127840-95-3
Molecular Formula:C₃₀H₂₈F₂N₂O₅
Molecular Weight:534.56
Hs Code.:

Synonyms:1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 5 articles about 1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 127840-92-0
1-(2-deoxy-2-fluoro-5-O-monomethoxytrityl-β-D-xylofuranosyl)thymine

: 127840-95-3
1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; for 8h; Ambient temperature;

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 127840-95-3
1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) NaOH / 1.) 60 deg C, 18 h, 2.) dioxane-methanol-water, room temperature overnight, reflux 30 min

3: trifluoromethanesulfonic anhydride, pyridine, 2.) NaOH / 1.) dichloromethane, 0 deg C, 1 h, 2.) dioxane-water, room temperature, 3 h

4: 100 percent / NaOH / dioxane

5: 64 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; sodium hydroxide; diethylamino-sulfur trifluoride; trifluoromethanesulfonic acid anhydride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 127840-90-8
3-(3,5-di-O-monomethoxytrityl-β-D-arabinofuranosyl)thymine

: 127840-95-3
1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

2: trifluoromethanesulfonic anhydride, pyridine, 2.) NaOH / 1.) dichloromethane, 0 deg C, 1 h, 2.) dioxane-water, room temperature, 3 h

3: 100 percent / NaOH / dioxane

4: 64 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; sodium hydroxide; diethylamino-sulfur trifluoride; trifluoromethanesulfonic acid anhydride; In 1,4-dioxane; dichloromethane;