1,4-Bis(3-methylphenyl)-1,4-butandion

Base Information

• Chemical Name: 1,4-Bis(3-methylphenyl)-1,4-butandion
• CAS No.: 78007-36-0
• Molecular Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.34
• Mol file: 78007-36-0.mol

Synonyms:1,4-Bis(3-methylphenyl)-1,4-butandion

Chemical Property of 1,4-Bis(3-methylphenyl)-1,4-butandion

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1,4-Bis(3-methylphenyl)-1,4-butandion

There total 2 articles about 1,4-Bis(3-methylphenyl)-1,4-butandion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-bromo-3'-methylacetophenone (51012-64-7) → 1,4-Bis(3-methylphenyl)-1,4-butandion (78007-36-0)

Guidance literature:

With rongalite; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02486

Reference yield: 39.0%

Divinyl sulfone (77-77-0) + m-tolyl aldehyde (620-23-5) → 1,4-Bis(3-methylphenyl)-1,4-butandion (78007-36-0)

Guidance literature:

With sodium acetate; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide; In ethanol; 1) 3 h, 80 deg C, 2) 12 h, reflux;

Reference yield: 79.0%

1,4-diphenylbut-2-ene (13657-49-3) + 1,4-Bis(3-methylphenyl)-1,4-butandion (78007-36-0) → (±)-(1',2',3',4'-tetrahydro-[1,1':4',1''-terphenyl]-2',3'-diyl)bis(m-tolylmethanone)

Guidance literature:

With copper(l) iodide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 4,4'-di-tert-butyl-2,2'-bipyridine; at 115 ℃; for 120h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c02486

upstream raw materials:

Divinyl sulfone

m-tolyl aldehyde

2-bromo-3'-methylacetophenone