13657-49-3Relevant articles and documents
Expanding the Family of Hoveyda-Grubbs Catalysts Containing Unsymmetrical NHC Ligands
Paradiso, Veronica,Bertolasi, Valerio,Costabile, Chiara,Caruso, Tonino,D?browski, Micha?,Grela, Karol,Grisi, Fabia
, p. 3692 - 3708 (2017)
A series of Hoveyda-Grubbs second-generation catalysts containing N-alkyl/N′-aryl N-heterocyclic carbene (NHC) ligands were synthesized and investigated in representative olefin metathesis reactions. Steric perturbations of unsymmetrical NHCs were achieved through modulation of the hindrance of alkyl (neopentyl, neophyl, cyclohexyl) and aryl (2-isopropylphenyl, mesityl) substituents at the nitrogen atoms in combination with different backbone configurations (syn and anti). The NHC substitution patterns strongly influence the stability and reactivity of the corresponding complexes. In general, complexes bearing an anti NHC backbone are more stable and more active than their corresponding syn isomers. In both the series, the presence of bulky, highly branched N-alkyl groups tends to give reduced catalytic differences between syn and anti isomers, whereas the nature of the N′-aryl substituent (2-isopropylphenyl or mesityl) gives rise to different activity and/or selectivity. Of note, an N′-mesityl catalyst with anti backbone was found to be highly competent in the ethenolysis of ethyl oleate, achieving up to 90% selectivity for the formation of terminal olefins.
Enantioselective Synthesis of Functionalized Arenes by Nickel-Catalyzed Site-Selective Hydroarylation of 1,3-Dienes with Aryl Boronates
Marcum, Justin S.,Meek, Simon J.,Taylor, Tiffany R.
supporting information, p. 14070 - 14075 (2020/06/10)
A catalytic method for the site-selective and enantioselective synthesis of functionalized arenes by the intermolecular hydroarylation of terminal and internal 1,3-dienes with aryl pinacolato boronates is reported. The reactions are promoted by 5.0 mol %
Preparation method of phenylacetaldehyde
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Paragraph 0055-0064; 0077-0080, (2020/04/17)
The invention discloses a preparation method of phenylacetaldehyde. The method comprises the following steps: taking 1, 4-diphenyl-2-butyne as a raw material, performing Lindelar catalytic hydrogenation reaction to obtain an intermediate 1, 4-diphenyl-2-butene, and performing ozonization and catalytic reduction reaction on the intermediate to obtain phenylacetaldehyde. According to the method, simple raw materials are adopted, through hydrogenation and ozonization conversion, the reaction process is environmentally friendly, the product yield is high, few byproducts are produced, and extremelyhigh atom economy is achieved.