Technology Process of 3-(2-phenylethyl)-α-(2-tetrahydropyranyloxy)-2-benzofuranacetonitrile
There total 5 articles about 3-(2-phenylethyl)-α-(2-tetrahydropyranyloxy)-2-benzofuranacetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / K2CO3 / acetone / 24 h / Heating
2: 84 percent / Na2CO3 / H2O / 3 h / Heating
3: 88 percent / NaOAc, Ac2O / 2 h / Heating
4: 95.6 percent / POCl3 / 100 °C
5: 96.8 percent / 6 M HCl, glacial acetic acid / H2O; diethyl ether / 5 °C
6: 68 percent / p-toluenesulfonic acid / CH2Cl2 / 1 h / Ambient temperature
With
hydrogenchloride; sodium acetate; acetic anhydride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; trichlorophosphate;
In
diethyl ether; dichloromethane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / NaOAc, Ac2O / 2 h / Heating
2: 95.6 percent / POCl3 / 100 °C
3: 96.8 percent / 6 M HCl, glacial acetic acid / H2O; diethyl ether / 5 °C
4: 68 percent / p-toluenesulfonic acid / CH2Cl2 / 1 h / Ambient temperature
With
hydrogenchloride; sodium acetate; acetic anhydride; toluene-4-sulfonic acid; acetic acid; trichlorophosphate;
In
diethyl ether; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / Na2CO3 / H2O / 3 h / Heating
2: 88 percent / NaOAc, Ac2O / 2 h / Heating
3: 95.6 percent / POCl3 / 100 °C
4: 96.8 percent / 6 M HCl, glacial acetic acid / H2O; diethyl ether / 5 °C
5: 68 percent / p-toluenesulfonic acid / CH2Cl2 / 1 h / Ambient temperature
With
hydrogenchloride; sodium acetate; acetic anhydride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; trichlorophosphate;
In
diethyl ether; dichloromethane; water;