3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine

Base Information

• Chemical Name: 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine
• CAS No.: 146366-94-1
• Molecular Formula: C₂₆H₃₃NO₃
• Molecular Weight: 407.553
• Mol file: 146366-94-1.mol

Synonyms:3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine

Chemical Property of 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine

There total 14 articles about 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N-(2-(3-(2-phenylethyl)-2-benzofuranyl)-2-(2-tetrahydropyranyloxy)ethyl)propanamide → 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine (146366-94-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; Ambient temperature;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine (146366-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TSA

With toluene-4-sulfonic acid;

DOI:10.1021/jm960384x

Reference yield:

3-(2-phenylethyl)benzofuran (85148-33-0) → 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine (146366-94-1)

Guidance literature:

Multi-step reaction with 5 steps

1: BF₃

2: Br₂, AlCl₃

3: LiAlH₄

4: p-TSA

With lithium aluminium tetrahydride; aluminium trichloride; boron trifluoride; bromine; toluene-4-sulfonic acid;

DOI:10.1021/jm960384x

upstream raw materials:

propylamine

3,4-dihydro-2H-pyran

3-(2-phenylethyl)benzofuran

1-(3-phenylethylbenzofuran-2-yl)ethan-1-one