(3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene

Base Information

Chemical Name:(3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene
CAS No.:122074-98-0
Molecular Formula:C₁₇H₃₆O₂Si₂
Molecular Weight:328.643
Hs Code.:

Synonyms:(3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene

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Technology Process of (3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene

There total 1 articles about (3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16029-98-4
trimethylsilyl iodide

: 122052-53-3
(2R,3R,4R)-(-)-4-(tert-butyldimethylsiloxy)-2,3-dimethylcyclohexanone

: 122074-98-0
(3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene

Guidance literature:: With 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86136-6

Reference yield: 58.0%

: 122074-98-0
(3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene

: 78-94-4,25038-87-3
methyl vinyl ketone

: 122052-54-4
(2R,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-2,3-dimethyl-2-(3-oxobutyl)cyclohexan-1-one

Guidance literature:: With boron trifluoride diethyl etherate; In nitromethane; isopropyl alcohol; at -20 ℃; for 2h;
DOI:10.1016/S0040-4020(01)86136-6

Reference yield:

: 122074-98-0
(3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene

: 88418-12-6
(3S,4R,4aR,5R,6R)-sporogen-AO 1

Guidance literature:: Multi-step reaction with 7 steps

1: 58 percent / BF₃*OEt₂ / propan-2-ol; nitromethane / 2 h / -20 °C

2: 79 percent / pyrrolidine / benzene / 2 h / Heating

3: 1.) LDA / 1.) -78 deg C, THF, 1.5 h, 2.) -78 deg C, THF, 15 min

4: 1.) SO₃*Py, DMSO, 2.) Et₃N

5: 70 percent / 4.17M t-BuOOH, 40percent triton B / tetrahydrofuran; toluene; methanol / Ambient temperature

6: 0.27 mmol / diethyl ether; tetrahydrofuran / 0.08 h / 0 °C

7: 1.) conc H₂SO₄, 2.) 48percent HF / 1.) THF, 3 d, room temp., 2.) CH₃CN, 30 min, room temp.

With pyrrolidine; tert.-butylhydroperoxide; pyridine-SO₃ complex; sulfuric acid; boron trifluoride diethyl etherate; hydrogen fluoride; N-benzyl-trimethylammonium hydroxide; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; nitromethane; isopropyl alcohol; toluene; benzene;
DOI:10.1016/S0040-4020(01)86136-6