(R)-2-benzyloxy-2-methylmalonic acid monoethyl ester

Base Information

• Chemical Name: (R)-2-benzyloxy-2-methylmalonic acid monoethyl ester
• CAS No.: 1786-91-0
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.267
• Mol file: 1786-91-0.mol

Synonyms:(R)-2-benzyloxy-2-methylmalonic acid monoethyl ester

Chemical Property of (R)-2-benzyloxy-2-methylmalonic acid monoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-benzyloxy-2-methylmalonic acid monoethyl ester

There total 5 articles about (R)-2-benzyloxy-2-methylmalonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-(benzyloxy)-2-methylmalonate (5774-69-6) → (R)-2-benzyloxy-2-methylmalonic acid monoethyl ester (1786-91-0) + (2S)-2-benzyloxy-3-ethoxy-2-methyl-3-oxo-propanoic acid (2006-97-5)

Guidance literature:

With horse liver acetone; Tris buffer; In n-heptane; water; at 20 ℃; for 25h; pH=7.5; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(01)00040-4

Reference yield:

diethyl 2-hydroxy-2-methylmalonate (58567-05-8) → (R)-2-benzyloxy-2-methylmalonic acid monoethyl ester (1786-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaH / dimethylformamide / 5 h / 20 °C

2: horse liver acetone powder; Tris buffer / H₂O; heptane / 25 h / 20 °C / pH 7.5

With horse liver acetone; Tris buffer; sodium hydride; In n-heptane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(01)00040-4

Reference yield:

benzyl bromide (100-39-0) → (R)-2-benzyloxy-2-methylmalonic acid monoethyl ester (1786-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaH / dimethylformamide / 5 h / 20 °C

2: horse liver acetone powder; Tris buffer / H₂O; heptane / 25 h / 20 °C / pH 7.5

With horse liver acetone; Tris buffer; sodium hydride; In n-heptane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(01)00040-4

upstream raw materials:

2-Benzyloxy-3-hydroxy-2-methyl-propionic acid ethyl ester

diethyl 2-(benzyloxy)-2-methylmalonate

diethyl 2-hydroxy-2-methylmalonate

benzyl bromide

Downstream raw materials:

(R)-ethyl 2-(benzyloxy)-2-methyl-3-hydroxypropionate

(+)-(S)-2-Benzyloxy-2-methylmalonyl monoethyl ester monochloride