(2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol

Base Information

Chemical Name:(2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol
CAS No.:780773-47-9
Molecular Formula:C₁₉H₂₃F₉O₃
Molecular Weight:470.375
Hs Code.:

Synonyms:(2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol

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Chemical Property of (2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol

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Technology Process of (2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol

There total 6 articles about (2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 780772-27-2
(2R,4S,5S)-4,5-Dimethyl-2-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-phenyl]-[1,3]dioxane

: 780773-47-9
(2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jo051526a

Reference yield:

: (2S,3S)-2-methyl-1,3-bis(trimethylsilanyloxy)butane

: 780773-47-9
(2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl triflate / CH₂Cl₂ / 12 h / -78 °C

2: DIBAL / CH₂Cl₂; hexane / 3 h / 0 °C

With trimethylsilyl trifluoromethanesulfonate; diisobutylaluminium hydride; In hexane; dichloromethane; 1: Noyori ketalization;
DOI:10.1021/jo051526a

Reference yield:

: 871028-89-6
4-nitrobenzoic acid (1S,2R)-2-ethoxycarbonyl-1-methylpropyl ester

: 780773-47-9
(2S,3S)-2-Methyl-3-[4-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyloxy)-benzyloxy]-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / lithium borohydride / tetrahydrofuran / 24 h / 20 °C

2: triethylamine / tetrahydrofuran / 16 h / 20 °C

3: trimethylsilyl triflate / CH₂Cl₂ / 12 h / -78 °C

4: DIBAL / CH₂Cl₂; hexane / 3 h / 0 °C

With lithium borohydride; trimethylsilyl trifluoromethanesulfonate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 3: Noyori ketalization;
DOI:10.1021/jo051526a