(2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate

Base Information

Chemical Name:(2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate
CAS No.:1222196-27-1
Molecular Formula:C₂HF₃O₂*C₁₃H₁₆FNO₂
Molecular Weight:351.298
Hs Code.:

Synonyms:(2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate

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Chemical Property of (2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate

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Technology Process of (2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate

There total 1 articles about (2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1222196-25-9
(2S,4R)-di-tert-butyl 4-(4-fluoro-2-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylate

: 76-05-1
trifluoroacetic acid

: 1222196-27-1
(2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate

Guidance literature:: (2S,4R)-di-tert-butyl 4-(4-fluoro-2-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylate; With lithium triethylborohydride; In tetrahydrofuran; at -78 ℃; for 0.5h;

With sodium hydrogencarbonate; In tetrahydrofuran;

trifluoroacetic acid;

Reference yield: 76.8%

: 24424-99-5
di-tert-butyl dicarbonate

: 1222196-27-1
(2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate

: 1222196-24-8
(2S,4R)-1-(tert-butoxycarbonyl)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid

Guidance literature:: di-tert-butyl dicarbonate; (2S,4R)-4-(4-fluoro-2-methylbenzyl)pyrrolidine-2-carboxylic acid trifluoroacetate; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In water;

With 1-hydroxy-1,1,2-ethanetricarboxylic acid; In water; pH=4;