2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione

Base Information

• Chemical Name: 2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione
• CAS No.: 1309774-76-2
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379

Synonyms:2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione

Chemical Property of 2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

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Technology Process of 2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione

There total 2 articles about 2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S)-1-phenyl-ethylamine (2627-86-3) + (-)-2-[(2R)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione (181140-34-1) → 2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione (1309774-76-2)

Guidance literature:

In isopropyl alcohol; at 0 ℃; for 9h; Reflux;

DOI:10.1016/j.tetasy.2011.02.028

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) + (S)-N-glycidylphthalimide (161596-47-0) → 2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione (1309774-76-2)

Guidance literature:

In isopropyl alcohol; regioselective reaction; Reflux; Inert atmosphere;

DOI:10.1002/chir.21034

Reference yield: 84.0%

2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]amino]propyl]isoindoline-1,3-dione (1309774-76-2) → (2S)-1-amino-3-[[(1S)-1-phenylethyl]amino]propan-2-ol (1357474-58-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Reflux; Inert atmosphere;

DOI:10.1002/chir.21034

upstream raw materials:

(S)-1-phenyl-ethylamine

(-)-2-[(2R)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione

(S)-N-glycidylphthalimide

Downstream raw materials:

C₇₀H₉₂N₄O₈

(2S)-1-amino-3-[[(1S)-1-phenylethyl]amino]propan-2-ol

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