methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate

Base Information

• Chemical Name: methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate
• CAS No.: 1315305-59-9
• Molecular Formula: C₇₆H₁₀₂F₅N₅O₈
• Molecular Weight: 1308.67

Synonyms:methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate

Chemical Property of methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate

There total 13 articles about methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-octylboronic acid (28741-08-4) → methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate (1315305-59-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 30 h / 90 °C / Inert atmosphere

2.1: iron; acetic acid / ethanol / 2 h / Reflux

3.1: thionyl chloride / 4 h / Reflux

3.2: 4 h

4.1: iron; acetic acid / ethanol / 2 h / Reflux

5.1: thionyl chloride / 4 h / Reflux

5.2: 4 h

6.1: iron; acetic acid / ethanol / 2 h / Reflux

7.1: thionyl chloride / 4 h / Reflux

7.2: 4 h

8.1: iron; acetic acid / ethanol / 2 h / Reflux

9.1: thionyl chloride / 4 h / Reflux

9.2: 4 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; iron; potassium carbonate; acetic acid; In ethanol; water; toluene;

DOI:10.1021/ol201361f

Reference yield:

2-fluoro-3-nitrobenzoic acid methyl ester (946126-94-9) → methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate (1315305-59-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: N-Bromosuccinimide; sulfuric acid; trifluoroacetic acid / 6 h / 45 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 30 h / 90 °C / Inert atmosphere

3.1: iron; acetic acid / ethanol / 2 h / Reflux

4.1: thionyl chloride / 4 h / Reflux

4.2: 4 h

5.1: iron; acetic acid / ethanol / 2 h / Reflux

6.1: thionyl chloride / 4 h / Reflux

6.2: 4 h

7.1: iron; acetic acid / ethanol / 2 h / Reflux

8.1: thionyl chloride / 4 h / Reflux

8.2: 4 h

9.1: iron; acetic acid / ethanol / 2 h / Reflux

10.1: thionyl chloride / 4 h / Reflux

10.2: 4 h

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sulfuric acid; iron; potassium carbonate; acetic acid; trifluoroacetic acid; In ethanol; water; toluene;

DOI:10.1021/ol201361f

Reference yield:

methyl 2-fluoro-3-nitro-5-octylbenzoate (1315305-54-4) → methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate (1315305-59-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: iron; acetic acid / ethanol / 2 h / Reflux

2.1: thionyl chloride / 4 h / Reflux

2.2: 4 h

3.1: iron; acetic acid / ethanol / 2 h / Reflux

4.1: thionyl chloride / 4 h / Reflux

4.2: 4 h

5.1: iron; acetic acid / ethanol / 2 h / Reflux

6.1: thionyl chloride / 4 h / Reflux

6.2: 4 h

7.1: iron; acetic acid / ethanol / 2 h / Reflux

8.1: thionyl chloride / 4 h / Reflux

8.2: 4 h

With thionyl chloride; iron; acetic acid; In ethanol;

DOI:10.1021/ol201361f

upstream raw materials:

2-fluoro-3-nitrobenzoic acid methyl ester

2-fluoro-3-nitro-5-octylbenzoic acid

methyl 5-bromo-2-fluoro-3-nitrobenzoate

methyl 2-fluoro-3-nitro-5-octylbenzoate

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