Technology Process of 1-(4-methoxybenzyl)-3-methyl-3-(3,4,5-trifluorophenoxy)piperidin-2-one
There total 5 articles about 1-(4-methoxybenzyl)-3-methyl-3-(3,4,5-trifluorophenoxy)piperidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-methoxybenzyl)-3-(3,4,5-trifluorophenoxy)piperidin-2-one;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuryl dichloride / tetrahydrofuran / 18 h / -5 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C
3.1: potassium carbonate / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 0.5 h / 0 °C
4.1: sodium hydroxide; water / tetrahydrofuran / 48 h / 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 - 20 °C / Inert atmosphere
With
sulfuryl dichloride; water; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 0.5 h / 0 °C
2.1: sodium hydroxide; water / tetrahydrofuran / 48 h / 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 - 20 °C / Inert atmosphere
With
water; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
