tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate

Base Information

Chemical Name:tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate
CAS No.:835877-01-5
Molecular Formula:C₂₇H₃₆F₂N₂O₄S
Molecular Weight:522.657
Hs Code.:

Synonyms:tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate

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Chemical Property of tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate

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Technology Process of tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate

There total 1 articles about tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 527744-26-9
(3R)-3-(3,5-difluorophenyl)-3-(4-methanesulphonylphenyl)-propionaldehyde

: 135632-53-0
tert-butyl N-(4-piperidinylmethyl)carbamate

: 835877-01-5
tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 835877-01-5
tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate

: [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]amine dihydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 835877-01-5
tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulphonyl)phenyl]propyl}piperidin-4-yl)methyl]carbamate

: C₂₄H₃₂F₂N₂O₄S₂

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;