(4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

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Chemical Name:(4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine
CAS No.:251361-88-3
Molecular Formula:C₃₅H₃₆N₆O₄
Molecular Weight:604.709
Hs Code.:

Synonyms:(4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

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Chemical Property of (4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

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Technology Process of (4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

There total 2 articles about (4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 139091-30-8,109364-32-1
(S)-benzyl (1-(indol-3-yl)-3-oxopropan-2-yl)carbamate

: (4aS,5R)-5-Amino-2-benzyl-hexahydro-pyrido[1,2-c]pyrimidine-1,3-dione

: [(1S,2S)-2-((4aS,5R)-2-Benzyl-1,3-dioxo-octahydro-pyrido[1,2-c]pyrimidin-5-ylamino)-2-cyano-1-(1H-indol-3-ylmethyl)-ethyl]-carbamic acid benzyl ester

: 251361-88-3
(4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: [2-(2-benzyl-1,3-dioxo-octahydro-pyrido[1,2-c]pyrimidin-5-ylamino)-2-cyano-1-(1H-indol-3-ylmethyl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: With triethylamine; zinc(II) chloride; In methanol; at -20 - 0 ℃; for 16h;
DOI:10.1021/jm991078x

Reference yield:

: (4aR*,5S*)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: 251361-88-3
(4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 1 h / 20 °C

2: Et₃N; ZnCl₂ / methanol / 16 h / -20 - 0 °C

With triethylamine; trifluoroacetic acid; zinc(II) chloride; In methanol; dichloromethane; 1: acidolysis / 2: Condensation;
DOI:10.1021/jm991078x

Reference yield:

: 251361-88-3
(4aS,5R)-2-benzyl-5-[(1R,2S)-2-N-(benzyloxycarbonyl)amino-1-cyano-3-(indol-3-yl)-propyl]amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: 1053250-73-9
(2R,3S)-3-Amino-2-((4aS,5R)-2-benzyl-1,3-dioxo-octahydro-pyrido[1,2-c]pyrimidin-5-ylamino)-4-(1H-indol-3-yl)-butyronitrile

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 96h; under 2068.59 Torr;
DOI:10.1021/jm991078x