Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester

Base Information

• Chemical Name: Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester
• CAS No.: 609342-43-0
• Molecular Formula: C₁₁H₁₅ClN₆O₅
• Molecular Weight: 346.73
• Mol file: 609342-43-0.mol

Synonyms:Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester

Chemical Property of Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester

There total 2 articles about Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Acetic acid (1R,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-methylsulfanylmethoxy-cyclohexyl ester (609342-42-9) → Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester (609342-43-0)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/anie.200351354

Reference yield:

[(1S,2S,3R,4S,6R)-2-acetoxy-4,6-diazido-3-hydroxy-cyclohexyl] acetate (236115-61-0) → Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester (609342-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / AcOH; Ac₂O / 60 h / 20 °C

2: SO₂Cl₂ / CH₂Cl₂ / 0.5 h / 20 °C

With sulfuryl dichloride; acetic anhydride; acetic acid; In dichloromethane; 1: Pummerer rearrangement;

DOI:10.1016/j.bmcl.2005.08.027

Reference yield:

4-mercapto 7-trifluoromethyl quinoline (64415-07-2) + Acetic acid (1S,2R,3R,4S,6R)-2-acetoxy-4,6-diazido-3-chloromethoxy-cyclohexyl ester (609342-43-0) → Acetic acid (1R,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-(7-trifluoromethyl-quinolin-4-ylsulfanylmethoxy)-cyclohexyl ester (609342-52-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.200351354

upstream raw materials:

Acetic acid (1R,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-methylsulfanylmethoxy-cyclohexyl ester

[(1S,2S,3R,4S,6R)-2-acetoxy-4,6-diazido-3-hydroxy-cyclohexyl] acetate

Downstream raw materials:

Acetic acid (1S,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-([1,2,3]triazol-1-ylmethoxy)-cyclohexyl ester

Acetic acid (1S,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-([1,2,4]triazol-1-ylmethoxy)-cyclohexyl ester

Acetic acid (1S,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-(4-iodo-pyrazol-1-ylmethoxy)-cyclohexyl ester

Acetic acid (1S,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-(imidazol-1-ylmethoxy)-cyclohexyl ester