609342-52-1Relevant articles and documents
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides
Wang, Xiaojing,Migawa, Michael T.,Sannes-Lowery, Kristin A.,Swayze, Eric E.
, p. 4919 - 4922 (2007/10/03)
The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate
Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay
Ding, Yili,Hofstadler, Steven A.,Swayze, Eric E.,Risen, Lisa,Griffey, Richard H.
, p. 3409 - 3412 (2007/10/03)
A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin (1). The A-ring (shown in red) was replaced with a range of heterocycles. An ESIMS-based RNA-binding assay was used to screen the binding affinities of