tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

Base Information

Chemical Name:tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate
CAS No.:1373687-50-3
Molecular Formula:C₂₇H₂₅FN₆O₃
Molecular Weight:500.532
Hs Code.:

Synonyms:tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

Suppliers and Price of tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

There total 11 articles about tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373687-48-9
C₂₀H₂₃FN₄O₂

: 53234-55-2
5-cyano-pyridine-2-carboxylic acid

: 1373687-50-3
tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 1189785-36-1
1-(1-bromoprop-1-en-2-yl)-2-fluorobenzene

: 1373687-50-3
tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 65 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / tetrahydrofuran; water / 14 h / 70 °C

3.1: trimethylaluminum; ammonium chloride / toluene / 26 h / 100 °C

4.1: sulfuric acid / 14.5 h / 20 °C

4.2: 1 h / 0 °C

5.1: tetrahydrofuran / 15 h / 20 °C

6.1: ammonium chloride; iron / methanol; tetrahydrofuran / 1.5 h / 70 °C

7.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 1.5 h / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; trimethylaluminum; potassium acetate; iron; potassium carbonate; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 1373687-50-3
tert-butyl (3-(5-(5-cyanopicolinamido)-2-fluorophenyl)-3-methyl-3,4-dihydro-2,6-naphthyridin-1-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C

1.2: 1.5 h / 0 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 65 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / tetrahydrofuran; water / 14 h / 70 °C

4.1: trimethylaluminum; ammonium chloride / toluene / 26 h / 100 °C

5.1: sulfuric acid / 14.5 h / 20 °C

5.2: 1 h / 0 °C

6.1: tetrahydrofuran / 15 h / 20 °C

7.1: ammonium chloride; iron / methanol; tetrahydrofuran / 1.5 h / 70 °C

8.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 1.5 h / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; potassium tert-butylate; trimethylaluminum; potassium acetate; iron; potassium carbonate; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;