2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 779331-12-3
• Molecular Formula: C₂₀H₂₂BF₃O₃
• Molecular Weight: 378.199
• Mol file: 779331-12-3.mol

Synonyms:2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 2 articles about 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-(benzyloxy)-2-bromo-4-(trifluoromethyl)benzene (200956-32-7) + bis(pinacol)diborane (73183-34-3) → 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (779331-12-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 110 ℃; for 4h; Inert atmosphere;

Reference yield:

[2-(phenylmethoxy)-5-(trifluoromethyl)phenyl]-boronic acid (612833-41-7) + 2,3-dimethyl-2,3-butane diol (76-09-5) → 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (779331-12-3)

Guidance literature:

In diethyl ether; at 20 ℃; for 20h;

Reference yield:

2-bromo-pyridine (109-04-6) + 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (779331-12-3) → 2-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)pyridine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 100 ℃; for 12h; Inert atmosphere;

upstream raw materials:

[2-(phenylmethoxy)-5-(trifluoromethyl)phenyl]-boronic acid

2,3-dimethyl-2,3-butane diol

1-(benzyloxy)-2-bromo-4-(trifluoromethyl)benzene

bis(pinacol)diborane

Downstream raw materials:

2-(pyridin-2-yl)-4-(trifluoromethyl)phenol