(S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol

Base Information

Chemical Name:(S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol
CAS No.:902775-76-2
Molecular Formula:C₂₇H₃₆O₅Si
Molecular Weight:468.665
Hs Code.:

Synonyms:(S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol

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Chemical Property of (S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol

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Technology Process of (S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol

There total 6 articles about (S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid (3aS,6S,6aS)-4-hydroxy-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-ylmethyl ester

: 902775-76-2
(S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / imidazole / CH₂Cl₂ / 6 h / 0 - 20 °C

2: 40 percent / NaOMe / methanol / 12 h / 20 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -78 °C

4: diethyl ether / 3 h / -78 °C

With 1H-imidazole; oxalyl dichloride; sodium methylate; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; 3: Swern oxidation;
DOI:10.1016/j.tetlet.2006.04.054

Reference yield:

: 902775-75-1
[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-methanol

: 902775-76-2
(S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -78 °C

2: diethyl ether / 3 h / -78 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; 1: Swern oxidation;
DOI:10.1016/j.tetlet.2006.04.054

Reference yield:

: 902775-74-0
acetic acid 4-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-ylmethyl ester

: 902775-76-2
(S)-1-[(3aS,4S,6S,6aS)-4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-6-vinyl-dihydro-furo[3,4-d][1,3]dioxol-3a-yl]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / NaOMe / methanol / 12 h / 20 °C

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -78 °C

3: diethyl ether / 3 h / -78 °C

With oxalyl dichloride; sodium methylate; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; 2: Swern oxidation;
DOI:10.1016/j.tetlet.2006.04.054