(2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester

Base Information

• Chemical Name: (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester
• CAS No.: 184777-25-1
• Molecular Formula: C₁₆H₂₁NO₆S
• Molecular Weight: 355.412
• Mol file: 184777-25-1.mol

Synonyms:(2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester

Chemical Property of (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester

There total 6 articles about (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid (184777-24-0) → (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester (184777-25-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In acetonitrile;

DOI:10.1016/0960-894X(96)00443-X

Reference yield:

(2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid ethyl ester (184777-23-9) → (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester (184777-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / LiOH

2: 76 percent / DCC / acetonitrile

With lithium hydroxide; dicyclohexyl-carbodiimide; In acetonitrile;

DOI:10.1016/0960-894X(96)00443-X

Reference yield:

5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-4-methyl-pentan-2-one (117783-92-3) → (2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 4-nitro-phenyl ester (184777-25-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 66 percent / Ac₂O

2: 76 percent

3: 67 percent / TBAF

4: 93 percent / LiOH

5: 76 percent / DCC / acetonitrile

With lithium hydroxide; tetrabutyl ammonium fluoride; acetic anhydride; dicyclohexyl-carbodiimide; In acetonitrile;

DOI:10.1016/0960-894X(96)00443-X

upstream raw materials:

4-nitro-phenol

(2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid

(2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid ethyl ester

5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-4-methyl-pentan-2-one