Technology Process of 2,3,4-tri-O-benzyl-6-deoxy-6,6-difluoro-D-glucitol
There total 3 articles about 2,3,4-tri-O-benzyl-6-deoxy-6,6-difluoro-D-glucitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 25 ℃;
for 4.3h;
Cooling with ice;
DOI:10.1515/znb-2011-0809
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dimethyl sulfoxide; trifluoroacetic anhydride / dichloromethane / -78 °C
1.2: 24 h / -78 - 25 °C
2.1: diethylamino-sulfur trifluoride / dichloromethane / 96 h / 25 °C
3.1: sulfuric acid; acetic acid / water / 216 h / 85 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.3 h / 25 °C / Cooling with ice
With
lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; sulfuric acid; acetic acid; dimethyl sulfoxide; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; water;
1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1515/znb-2011-0809
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diethylamino-sulfur trifluoride / dichloromethane / 96 h / 25 °C
2: sulfuric acid; acetic acid / water / 216 h / 85 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 4.3 h / 25 °C / Cooling with ice
With
lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; sulfuric acid; acetic acid;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1515/znb-2011-0809
