Technology Process of 2,3,4-tri-O-benzyl-1,6-dideoxy-6,6-difluoro-L-isonojirimycin
There total 7 articles about 2,3,4-tri-O-benzyl-1,6-dideoxy-6,6-difluoro-L-isonojirimycin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride;
In
methanol;
at -78 - 50 ℃;
for 74h;
DOI:10.1515/znb-2011-0809
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dimethyl sulfoxide; trifluoroacetic anhydride / dichloromethane / -78 °C
1.2: 1 h / -78 - 25 °C
2.1: acetic acid; sodium sulfate / methanol / 2 h / -78 °C
3.1: sodium cyanoborohydride / methanol / 74 h / -78 - 50 °C
With
sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; sodium sulfate; trifluoroacetic anhydride;
In
methanol; dichloromethane;
1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1515/znb-2011-0809
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; acetic acid / water / 216 h / 85 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.3 h / 25 °C / Cooling with ice
3.1: dimethyl sulfoxide; trifluoroacetic anhydride / dichloromethane / -78 °C
3.2: 1 h / -78 - 25 °C
4.1: acetic acid; sodium sulfate / methanol / 2 h / -78 °C
5.1: sodium cyanoborohydride / methanol / 74 h / -78 - 50 °C
With
lithium aluminium tetrahydride; sulfuric acid; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; sodium sulfate; trifluoroacetic anhydride;
In
tetrahydrofuran; methanol; dichloromethane; water;
3.1: Swern oxidation / 3.2: Swern oxidation;
DOI:10.1515/znb-2011-0809
