N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

Base Information

Chemical Name:N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal
CAS No.:105089-73-4
Molecular Formula:C₁₇H₂₆N₂OS₂
Molecular Weight:338.538
Hs Code.:

Synonyms:N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Chemical Property of N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Technology Process of N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 5 articles about N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 105089-72-3
N-(5-methyl-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 105089-73-4
N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: With tin(ll) chloride; In methanol; for 1.5h; Heating;
DOI:10.1021/jo00377a016

Reference yield:

: 100230-83-9
N-(5-methyl-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde

: 105089-73-4
N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / trimethylsilyl chloride / CHCl₃

2: 96 percent / stannous chloride dihydrate / methanol / 1.5 h / Heating

With chloro-trimethyl-silane; tin(ll) chloride; In methanol; chloroform;
DOI:10.1021/jo00377a016

Reference yield:

: 105089-71-2
N-(5-methyl-2-nitrobenzoyl)proline

: 105089-73-4
N-(2-amino-5-methylbenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride / benzene / 1 h

2: benzene / 1 h

3: diisobutylaluminium hydride (DIBAL) / hexane; toluene / 0.5 h / -78 °C

4: 89 percent / trimethylsilyl chloride / CHCl₃

5: 96 percent / stannous chloride dihydrate / methanol / 1.5 h / Heating

With chloro-trimethyl-silane; oxalyl dichloride; diisobutylaluminium hydride; tin(ll) chloride; In methanol; hexane; chloroform; toluene; benzene;
DOI:10.1021/jo00377a016