[(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester

Base Information

Chemical Name:[(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester
CAS No.:78028-95-2
Molecular Formula:C₁₆H₂₃NO₃
Molecular Weight:277.364
Hs Code.:

Synonyms:[(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester

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Chemical Property of [(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester

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Technology Process of [(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester

There total 1 articles about [(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 6456-74-2
Glycine tert-butyl ester

: 42843-18-5
(3R)-3-hydroxy-3-phenylbutan-2-one

: 78028-95-2
[(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In benzene; Heating;
DOI:10.1246/cl.1981.279

Reference yield:

: 78028-95-2
[(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester

: 81366-42-9
(2S,3S)-2-Benzyloxycarbonylamino-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butylmagnesium chloride, 2.) potassium diisopropylamide / 1.) THF, -78 deg C -> room temperature, 2.) ether, -123 deg C, 5 min

2: tetrahydrofuran / -128 deg C -> room temperature

With butyl magnesium bromide; potassium diisopropylamide; In tetrahydrofuran;
DOI:10.1246/cl.1982.145

Reference yield:

: 78028-95-2
[(R)-2-Hydroxy-1-methyl-2-phenyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester

: 81366-41-8
(2R,3S)-2-Benzyloxycarbonylamino-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butylmagnesium chloride, 2.) potassium diisopropylamide / 1.) THF, -78 deg C -> room temperature, 2.) ether, -123 deg C, 5 min

2: tetrahydrofuran / -128 deg C -> room temperature

With butyl magnesium bromide; potassium diisopropylamide; In tetrahydrofuran;
DOI:10.1246/cl.1982.145