4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid

Base Information

Chemical Name:4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid
CAS No.:1454676-41-5
Molecular Formula:C₁₉H₂₁N₅O₄S
Molecular Weight:415.473
Hs Code.:

Synonyms:4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid

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Chemical Property of 4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid

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Technology Process of 4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid

There total 7 articles about 4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1454676-36-8
4-(hydroxycarbamoyl)benzenesulfonyl chloride

: 137898-68-1
1-methyl-2-(1-piperazinyl)-1H-benzimidazole

: 1454676-41-5
4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 23h;
DOI:10.1016/j.bmcl.2013.07.047

Reference yield:

: C₂₂H₂₄N₄O₆S

: 1454676-41-5
4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In ethanol; at 0 - 20 ℃; for 1h;
DOI:10.1371/journal.pone.0134556

Reference yield:

: 4857-06-1
2-chloro-1H-benzoimidazole

: 1454676-41-5
4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / 2 h / 20 °C

2: neat (no solvent) / 1 h / 125 °C

3: hydrogen bromide / water / 24 h / 70 °C

4: triethylamine / dichloromethane / 23 h / 0 - 20 °C

With hydrogen bromide; triethylamine; sodium hydroxide; In dichloromethane; water;
DOI:10.1016/j.bmcl.2013.07.047