4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester
CAS No.:889101-57-9
Molecular Formula:C₂₀H₂₇ClN₂O₃
Molecular Weight:378.899
Hs Code.:

Synonyms:4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-24-7
acetic anhydride

: 732275-75-1
tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate

: 889101-57-9
4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate; MeLi*LiBr; In various solvent(s); at -30 - -10 ℃;

acetic anhydride; In various solvent(s); at -50 - 20 ℃;
DOI:10.1021/ol061318k

Reference yield:

: 917-54-4
methyllithium

: 108-24-7
acetic anhydride

: 732275-75-1
tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate

: 889101-57-9
4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: methyllithium; tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate; With lithium bromide; In tetrahydrofuran; Isopropylbenzene; tert-butyl methyl ether; at -15 - -10 ℃; for 1h;

acetic anhydride; In tetrahydrofuran; Isopropylbenzene; tert-butyl methyl ether; at -50 - 20 ℃;

With water; In tetrahydrofuran; Isopropylbenzene; tert-butyl methyl ether; at 20 ℃; for 0.333333h; Product distribution / selectivity;

Reference yield:

: methyllithium lithium bromide

: 108-24-7
acetic anhydride

: 732275-75-1
tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate

: 889101-57-9
4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: methyllithium lithium bromide; tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate; In diethyl ether; tert-butyl methyl ether; at -20 - -10 ℃; for 1h;

acetic anhydride; In diethyl ether; tert-butyl methyl ether; at -50 - 20 ℃;

With sodium hydroxide; water; more than 3 stages; Product distribution / selectivity;