732275-75-1

Basic information

• Product Name: tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate
• CAS NO: 732275-75-1
• Molecular Weight: 320.819
• Mol File: 732275-75-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate(732275-75-1)
• EPA Substance Registry System: tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate(732275-75-1)

Safety Data

• Hazardous Substances Data: 732275-75-1(Hazardous Substances Data)

Upstream product

• 819070-55-8 tert-butyl 4-(4-chloro-2-cyanophenyl)-3,6-dihydropyridine-1(2H)-carboxylate 
• 865-47-4 potassium tert-butylate 
• 757976-84-4 benzyl 4-(4-chloro-2-cyanophenyl)pyridine-1(4H)-carboxylate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 819070-53-6 (4-chloro-2-cyanophenyl)boronic acid 
• 57381-37-0 2-bromo-5-chloro-benzonitrile 
• 766-84-7 3-chloro-benzonitrile 
• 110-86-1 pyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 757976-86-6 benzyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate 
• 757976-80-0 phenyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate 
• 301673-14-3 tert-butyl 4-iodopiperidine-1-carboxylate 

Downstream Products

• 889101-57-9 4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Rapid identification of a scalable catalyst for the asymmetric hydrogenation of a sterically demanding aryl enamide

High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an intermediate towards a new potent melanocortin receptor agonist useful in the treatment of obesity.

An efficient synthesis of a highly functionalized 4-arylpiperidine

In this manuscript, an efficient synthesis of a functionalized 4-arylpiperidine is disclosed. Several synthetic approaches towards formation of the key aryl-piperidine sp3 carbon-carbon bond are discussed, including a scalable route to the piperidine via

Process and intermediates for the preparation of 4-aryl piperidines

A novel process is provided for the preparation of 4-aryl piperidines, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of disorders such as obesity, diabetes, male sexual dysfunction, and female sexual dysfunction.