methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate

Base Information

Chemical Name:methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate
CAS No.:1191069-80-3
Molecular Formula:C₂₃H₁₉ClF₃NO₄S
Molecular Weight:497.922
Hs Code.:

Synonyms:methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate

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Chemical Property of methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate

Chemical Property:

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Technology Process of methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate

There total 2 articles about methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186212-02-1
methyl 4-(((4-chlorophenyl)sulfonamido)methyl)benzoate

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1191069-80-3
methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate

Guidance literature:: methyl 4-(((4-chlorophenyl)sulfonamido)methyl)benzoate; With sodium hydride; In N,N-dimethyl-formamide; at -30 ℃; for 0.25h;

4-bromomethyltrifluoromethylbenzene; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1191069-80-3
methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / -30 °C

2.2: 12 h / 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 91.0%

: 1191069-80-3
methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate

: 1191069-81-4
4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoic acid

Guidance literature:: methyl 4-({[(4-chlorophenyl)sulfonyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; for 12h; Cooling;

With citric acid; In tetrahydrofuran; water;