5-Amino-2-ethoxypyridine

Base Information

• Chemical Name: 5-Amino-2-ethoxypyridine
• CAS No.: 52025-34-0
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.17
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70199995
• Wikidata: Q72436606
• Mol file: 52025-34-0.mol

Synonyms:5-Amino-2-ethoxypyridine;52025-34-0;6-ethoxypyridin-3-amine;2-ethoxy-5-aminopyridine;3-Pyridinamine, 6-ethoxy-;Pyridine, 5-amino-2-ethoxy-;BRN 0116585;6-ethoxy-3-pyridinamine;2- ethoxy-5-aminopyridine;2-ethoxy-5-amino pyridine;6-(ethyloxy)-3-pyridinamine;SCHEMBL113044;3-AMINO-6-ETHOXYPYRIDINE;DTXSID70199995;UXIPFCIFZLFXNC-UHFFFAOYSA-N;6-ETHOXY-PYRIDIN-3-YLAMINE;MFCD01646194;AKOS000144831;AB09602;AC-19926;AC-23894;TS-01786;LS-130226;A7653;CS-0195502;FT-0659640;EN300-104174;O11589;J-516691;Z240084310

Chemical Property of 5-Amino-2-ethoxypyridine

Chemical Property:

• Melting Point: 67.5-68.5 °C
• Boiling Point: 269.5 °C at 760 mmHg
• PKA: 4.97±0.22(Predicted)
• Flash Point: 116.8 °C
• PSA: 48.14000
• Density: 1.101 g/cm³
• LogP: 1.64370
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-2-ethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC=C(C=C1)N
• Uses: 5-Amino-2-ethoxypyridine is a useful research reagent for the preparation of primaquine and primaquine analogs for the treatment of malarial.

Technology Process of 5-Amino-2-ethoxypyridine

There total 6 articles about 5-Amino-2-ethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-ethoxy-5-nitropyridine (31594-45-3) → 5-amino-2-ethoxypyridine (52025-34-0)

Guidance literature:

With methanol; 5%-palladium/activated carbon; Heating / reflux;

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 5-amino-2-ethoxypyridine (52025-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / Ambient temperature

2: hydrogen / 5 percent Pd/C / methanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00123a012

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 5-amino-2-ethoxypyridine (52025-34-0)

Guidance literature:

With sodium hydroxide; anschliessendes Hydrieren an Palladium/CaCO₃;

upstream raw materials:

5-bromo-2-ethoxypyridine

2-chloro-5-nitropyridine

2-ethoxy-5-nitropyridine

hydrogenchloride

Downstream raw materials:

N,N',N''-tris-(4-ethoxy-phenyl)-guanidine

sulfanilic acid-(6-ethoxy-[3]pyridylamide)

6-ethoxy-nicotinonitrile

diethyl 2-(6-ethoxy-pyridin-3-ylaminomethylene)malonate