α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone

Base Information

Chemical Name:α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone
CAS No.:72622-61-8
Molecular Formula:C₂₁H₂₀O₆
Molecular Weight:368.386
Hs Code.:

Synonyms:α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone

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Technology Process of α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone

There total 17 articles about α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 150715-15-4
(2E,3E)-3-(methoxycarbonyl)-2-((benzo[d][1,3]-dioxol-6-yl)methylene)-4-(3,4-dimethoxyphenyl)but-3-enoic acid

: 72622-61-8
α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone

Guidance literature:: With ethanol; sodium; for 6h; Ambient temperature;

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 72622-61-8
α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / t-BuOH / 2-methyl-propan-2-ol / 0.5 h / 40 °C

2: 93 percent / H₂ / 10percent Pd/C / methanol / 6 h / 760 Torr

3: 1.) t-BuOK, 2.) NaBH₄, CaCl₂ / 1.) EtOH, 2.) EtOH, RT, 12 h

4: 1.) LDA / 1.) hexane, THF, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 1 h

5: Et₃N, 4-(dimethylamino)pyridine / tetrahydrofuran / 5 h / Ambient temperature

6: NaH / tetrahydrofuran / 12 h / Ambient temperature

With dmap; sodium tetrahydroborate; potassium tert-butylate; hydrogen; sodium hydride; triethylamine; calcium chloride; tert-butyl alcohol; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; tert-butyl alcohol;
DOI:10.1246/bcsj.69.2281

Reference yield:

: 78647-51-5
4-[3,4-dimethoxyphenyl]-3-(methoxycarbonyl)-3-butenoic acid

: 72622-61-8
α-(trans-3',4'-methylenedioxybenzylidene)-β-(3,4-dimethoxybenzyl)-γ-butyrolactone

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / H₂ / 10percent Pd/C / methanol / 6 h / 760 Torr

2: 1.) t-BuOK, 2.) NaBH₄, CaCl₂ / 1.) EtOH, 2.) EtOH, RT, 12 h

3: 1.) LDA / 1.) hexane, THF, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 1 h

4: Et₃N, 4-(dimethylamino)pyridine / tetrahydrofuran / 5 h / Ambient temperature

5: NaH / tetrahydrofuran / 12 h / Ambient temperature

With dmap; sodium tetrahydroborate; potassium tert-butylate; hydrogen; sodium hydride; triethylamine; calcium chloride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1246/bcsj.69.2281