4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

Base Information

Chemical Name:4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate
CAS No.:1344685-92-2
Molecular Formula:C₁₆H₇F₈NO₃
Molecular Weight:413.224
Hs Code.:

Synonyms:4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

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Chemical Property of 4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

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Technology Process of 4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

There total 5 articles about 4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1327280-81-8
3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

: 1344685-92-2
4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

Guidance literature:: With tetrakis(acetonitrile)palladium bistriflate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In 1-methyl-pyrrolidin-2-one; acetonitrile; at 120 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201102985

Reference yield: 37.0%

: 1344685-92-2
4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

Guidance literature:: With 1-methyl-pyrrolidin-2-one; Pd(OTf)₂(CH₃CN)₄; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In acetonitrile; at 120 ℃; for 2h; Inert atmosphere; Schlenk technique; Sealed tube;

Reference yield:

: 6304-89-8
3-acetoxybenzoic acid

: 1344685-92-2
4-fluoro-3-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)carbamoyl)phenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 0 - 20 °C / Inert atmosphere

2: toluene / 28 h / 20 °C / Reflux

3: tetrakis(acetonitrile)palladium bistriflate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate / 1-methyl-pyrrolidin-2-one; acetonitrile / 24 h / 120 °C / Inert atmosphere

With tetrakis(acetonitrile)palladium bistriflate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In 1-methyl-pyrrolidin-2-one; toluene; acetonitrile;
DOI:10.1002/anie.201102985